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FIGURE 5 The primary source of ROS in the endoplasmic reticulum is the formation of intramolecular disulfide bonds during the maturation of many secreted proteins and membrane proteins

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Sources: Novinscak T, Brcic L, Staresinic M, et al

In certain cancer types, including gastric, breast, renal clear cell, colorectal and endometrial cancer, and myeloid leukemia, the absence of GPX3 expression often indicates a poor prognosis and the development of resistance to chemotherapy in patients (2)