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Notably, higher serum choline levels correlated with improved progression-free survival and a trend toward better overall survival (235)

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This signaling cascade subsequently elevates ACSL4 expression, driving lipid peroxidation and ferroptosis through the ACSL4/lysophosphatidylcholine acyltransferase 3/arachidonate lipoxygenase 15 axis, as demonstrated in both in vitro and in vivo models of severe acute pancreatitis (114)

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