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The drug was demonstrated to produce dramatic weight loss in trials of non-diabetics

Furthermore, it has been reported that lysosomes, peroxisomes, Golgi apparatus, endoplasmic reticulum (ER), and ribosomes are also cleared from the erythroid lineage cells in an autophagy-dependent fashion [32, 36]

75 While excessive activation of THR may lead to cardiac abnormalities, 42 specific THR activators primarily target the liver, inducing hepatic fatty acid oxidation and reducing steatosis and hyperlipidemia in rats and mice with genetically or diet-induced T2DM

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Exenatide formulations show variable nausea rates: the twice-daily immediate-release preparation (Byetta) tends to produce higher rates of nausea (approximately 3050%), whilst the once-weekly extended-release formulation (Bydureon) demonstrates improved tolerability with nausea rates of approximately 1424%, according to their respective SmPCs

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