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Despite the absence of a statistically significant doseresponse relationship observed in this analysis, clinical decision-making should consider that absorption efficiencyrather than absolute dosagemay be the limiting factor

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* Correspondence: Vishwanath Venketaraman, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers