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it may reflect drug classmediated activation of other cardiovascular protective mechanisms

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Efficacy and safety of sitagliptin versus glipizide in patients with type 2 diabetes and moderate-to-severe chronic renal insufficiency

Published in the New England Journal of Medicine, this trial enrolled 2,539 adults with obesity or overweight (with at least one weight-related comorbidity) who did not have diabetes

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I think it's unreasonable to think that you can go back the way you were and you're going to keep your weight off, because that's just not how physiology works