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Starting in 2022, high demand led to shortages of semaglutide injections sold by Novo Nordisk under the brand names Ozempic and Wegovy, as well as tirzepatide injections Zepbound and Mounjaro from Eli Lilly

Scientists originally developed them to treat type 2 diabetes, but research shows they also promote weight loss when paired with healthy habits

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Others benefit from longer-term therapy to support metabolic stability or maintain weight loss

Notably, GLP-1 signaling helps regulate higher-order central nervous system functions, including learning and memory, reward processing, and food palatability

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