Ozempic has not been approved for weight loss, though the higher-dose Wegovy has for certain overweight people
However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)
It scored 4.8 to Ros 4.0 in our reviews, and that gap is mostly about value and ease
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Chemically, trimethylamine and similar volatile amines are the main culprits