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The NOTCH pathway, known for its role in cancer stemness and epithelialmesenchymal transition, is another promising target, with gamma-secretase inhibitors (e.g., nirogacestat) currently in early-phase trials

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At t = 4 h, cells were serum starved and at t = 1 h, pre-treated with vehicle, control IgG1, or L2-Cmu (100 g/mL)

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