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These were predominantly mild to moderate and occurred mainly during dose escalation

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This results in the recruitment of immune cells and the release of pro-inflammatory cytokines, which in turn influence keratinocyte and fibroblast activity [43, 47]

In addition to profoundly compromising quality of life and daily functioning, this disorder contributes to the pathogenesis of numerous chronic diseasesincluding hypertension, coronary artery disease, stroke, diabetes, and cognitive impairmentand has been correlated with elevated all-cause mortality risk (46)

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