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Aim for a 2-minute hold minimum and build from there

It is inherently produced by the body and plays an essential role in the regulation of blood sugar levels and appetite control

The study, called the Cessation or Reduction of Alcohol Consumption in Veterans trial, will enroll more than 600 veterans ages 18 to 80 at 18 VA medical centers across the country

Furihata K et al (2022) A phase 1 multiple-ascending dose study of tirzepatide in Japanese participants with type 2 diabetes

,2013,5 (3): 183-186

The exact damage threshold isn't published per minute of exposure, but the conservative assumption is that an hour at 95F or more is enough to see measurable potency loss in semaglutide and tirzepatide