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10.1371/journal.pone.0166125 180 TahraniA
In clinical trials, people taking semaglutide lost an average of 15% in a little over a year (even more for those taking Wegovy HD), while those on tirzepatide lost an average of 21% in roughly the same time
In these individuals, there were actual changes found in their gene expression relating to fatty acid metabolism (including carnitine acetyltransferase) and mitochondrial dysfunction
Domperidone isn't FDA-approved in the US
The longer it stays above 46 degrees, the more degradation occurs
This selective action means that natural rewards like social connection and achievement remain pleasurable while drug-induced dopamine spikes are blunted
