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Both doses of orforglipron lowered blood sugar more than both doses of semaglutide
Tirzepatide, a dual GLP-1 / glucose-dependent insulinotropic polypeptide (GIP) agonist, was superior to semaglutide in reducing HbA 1c and body weight in the SURPASS-2 trial, a phase 3, randomised, open-label trial comparing the efficacy and safety of tirzepatide vs semaglutide once weekly as add-on therapy to metformin in individuals with type 2 diabetes [10]
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CagriSema may serve those who need greater weight reduction, particularly patients with type 2 diabetes where REDEFINE-2 data are strongest [7]
