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In addition, further subgroup analyses for different ages and ADR also yielded negative results (Additional file 1: Fig S56)

The Pcob specific C-terminal five-helix globin domain does not contribute directly to the dimer interface, and is positioned such that it forms interactions with both of the B 12 -binding domains (i.e., Rossmann fold and four-helix bundle)

This translated into an absolute risk reduction of about 0.69%

start with the labeled dose and follow guidance from your clinician