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This shortage has been caused by high demand and production delays
J Biol Chem 1992, 267: 74027405
From 2030 to 2035, the market is forecast to grow from USD 39,528 million to USD 65,364 million, adding another USD 25836.0 million, which constitutes 45.2% of the overall ten-year expansion
Additionally, exposure of monocytes to homocysteine induces tissue factor (TF) expression (Khajuria and Houston, 2000), and exposure of endothelial cells to homocysteine increases TF expression (Fryer et al, 1993), and the activation of factor V to factor Va (Rodgers and Conn, 1990), thus favoring thrombin generation through initiation and propagation of the coagulation cascade
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