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Changes in inflammatory signaling pathways in adipose tissue during aging Nuclear factor-B (NF-B) serves as a vital mediator of inflammatory responses and regulates the survival, activation, and differentiation of immune cells [115]

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In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins

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