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The authors concluded that the oral hydrolyzed collagen and vitamin C showed benefits for skin, scalp, and hair parameters when used daily over a 12-week period [51]

*Antioxidants alone will not be effective in the majority of melasma cases

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Nevertheless, these studies collectively suggest potential benefits of lipoic acid for chemotherapy-induced neuropathy at daily doses ranging from 600 mg to 1,800 mg, though the larger trial underscores the need for well-designed regimens and careful patient adherence to confirm efficacy over extended treatment courses