The compound did not impact food intake, suggesting it works through metabolic enhancement rather than appetite suppression
The program established a favorable safety profile but the Phase IIb endpoint did not differentiate sufficiently from placebo to support continued development for obesity
In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
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Cyanocobalamin (cyanocobalamin): Side effects, uses, dosage