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Change in mitochondrial mass in HCT116 cells treated 5 M 5FU over 72 h measured by nonyl-acridine orange (NAO) staining ( b ) or mitochondrial DNA content ( c ), data point shows biological mean, s.e.m

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Phase 2 data suggests retatrutide may produce greater weight reduction than currently approved agents, but its long-term safety profile has not been fully established, and no head-to-head regulatory-grade trials have been completed

The F 1 complex is composed of three copies of both the and subunits and one copy of the , , and subunits