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The sterol regulatory element-binding protein (SREBP) family of transcription factors plays a crucial role in lipid metabolism by regulating the expression of a series of enzymes required for lipid synthesis, and nuclear fragments of transcriptionally active SREBPs (nSREBPs) are unstable, degraded by the ubiquitin-proteasome pathway
Treatment: if necessary, symptomatic treatment is carried out
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The CPT2 gene has a polymorphism found in about 1% of the population
NRF1 is also a member of CNC transcription factors, which can promote the resistance of cells to ferroptosis by maintaining the expression of GPX4, independent of NRF2
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