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Metformin Use with GLP-1 RA: Synergy Towards Better Outcomes Metformin with GLP-RA Effect on Weight-Lowering Response: A 52-week prospective study including 194 obese T2D patients showed concomitant initiation of metformin alongside GLP-1 receptor agonist therapy is associated with enhanced weight loss efficacy, suggesting a potential synergistic metabolic interaction that improves the likelihood of achieving clinically meaningful weight reduction

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Zepbound (tirzepatide) is an FDA-approved medication for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity such as hypertension, type 2 diabetes, dyslipidemia, or obstructive sleep apnea

Acknowledgements We thank the study subjects for participating in this clinical trial