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Retrieved 22 April 2022, from Watts D

For severe deficiency, the AAFP recommends loading doses typically daily or every other day for one to two weeks followed by monthly maintenance injections

Mechanism And Absorption Injections (IM or subcutaneous) Usually given as cyanocobalamin or hydroxocobalamin Absorbed directly from muscle or subcutaneous tissue into circulation Typically administered in a clinic, or self-injected after training B12 nasal spray Absorbed through the nasal mucosa directly into the bloodstream Avoids needles, first-pass metabolism, and GI issues Can be administered at home in seconds A quick side-by-side view can help: Clinical work with prescription cyanocobalamin nasal spray (e.g., Nascobal) shows that nasal B12 reaches effective blood levels and maintains them over time when used on a consistent schedule, with research from the Comparison of the Efficacy demonstrating superior absorption through nasal delivery compared to oral administration

Metformin and Vitamin B12 deficiency Reduced absorption of vitamin B12 is a side effect of long-term use of metformin

While these findings are intriguing, the leap from controlled laboratory settings to the complex biological environment of the human body is significant and uncertain

Were exploring gut health, personalized nutrition, IV therapy, and yes B12 injections