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Many investigational agents have targeted mitochondrial function, including TUDCA [8, 149]

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However, it is not proven if this actually leads to better results in humans

Relevant research variables include: Cell viability Barrier-associated markers Gene expression Protein secretion Matrix deposition Pigment-cell signaling Oxidative-response markers Histological organization Results from a skin-associated laboratory model do not establish anti-aging skincare, wrinkle reduction, improved texture, scar reduction, or cosmetic effectiveness

In the present study, the cecal microbiome differed significantly across treatment groups, despite tightly controlling for several variables known to alter the microbiome in rodents