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Mari-Anne Newman, University of Copenhagen, Denmark Updates Copyright 2018 Gullner, Komives, Kirly and Schrder

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Contribution margin per page assuming current = $0.20 $0.08 $0.07 = $0.05 per page fixed leasing agreement Fixed costs = $1,500 Fixed costs $1,500 30,000 pages Contribution margin per page $0.05 per page Breakeven point = New commission-based agreement Contribution margin per page assuming $10 per 500 page commission agreement = $0.20 $0.02a $0.08 $0.07 = $0.03 per page Fixed costs = $0 Fixed costs $0 0 pages Contribution margin per page $0.03 per page Breakeven point = (i.e., Sunshine makes a profit no matter how few pages it sells) a $10 500 pages = $0.02 per page 2

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STABILITY AND FORMULATION DOCUMENTATION Cagrilintide's relatively long half-life (~57 days) reflects molecular modifications enhancing stability