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Critically, in vitro binding or degradation does not guarantee efficacy in vivo due to the complex gastrointestinal environment, including variable pH, proteolytic enzymes, bile salts, and competition from resident microbiota (30, 94)

Adverse outcomes among patients on MTX include hepatotoxicity, hematotoxicity, testiculopathy, and lung problems (Shea et al., 2013)

Data are lacking from long-term studies to assess whether oral treatment is effective when doses are administered less frequently than daily

S2CID 3257666

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For our patients, this means they can take BPC-157 at home, as part of their daily routine