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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012

50% of patients find relief from gastrointestinal symptoms by adjusting their diet, confirming that diet changes are not guesswork but a high-yield first step

Preclinical models: Humanized GA models incorporating dietary/metabolic stressors are needed to recapitulate FA-immune interactions (241)

Journal of obesity, 2016

GLP-1 Agonist Sherman Oaks, CA GLP-1 agonists are drugs used to treat type 2 diabetes and obesity

Baseline Demographics and Medication Profiles A total of 125 youth were included (median age 14.83 years), with 113 on metformin and 12 on GLP-1RA therapy