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Previously, we established a link between impaired mitochondrial function and altered epithelial cell differentiation in the context of intestinal inflammation (9, 14, 64, 65)
The findings obtained from the SMART collaborative meta-analysis (SGLT2 Inhibitor Meta-Analysis Cardio-Renal Trialists), designed to evaluate the impact of SGLT2is on cardiovascular and renal outcomes based on the concomitant use or non-use of GLP1-RAs, included 12 controlled clinical trials with 73,238 participants, of whom 3065 (4.2%) received GLP1-RAs
Wen Z, Xia G, Liang C, Wang X, Huang J, Zhang L, Shan D, Wu S, Cao X
If you eat smaller meals, you put less food in your stomach at one time
This means that tirzepatide has the potential to improve glycemic control better than GLP1RAs [77, 83]
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