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Senescence was pronounced (~80% higher SPiDER-Gal expression over vehicle and ~2-fold that of STING-expressing cells

Immunoblot of LDLR, SCARB1, and UGDH in HeLa cells transduced with the indicated sgRNAs

Tirzepatides dual mechanism, which acts on both the GLP-1 and GIP receptors, appears to produce a somewhat milder GI side effect profile than semaglutide in several comparative studies, though individual responses vary considerably