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Description

These drugs work by mimicking GLP-1, a naturally occurring hormone made in the intestines

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Accordingly, these patients should be evaluated for orthostatic hypotension before starting therapy with a SGLT2i [11]

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Compared to the native hormones, retatrutide shows 2.9-fold less potency at the glucagon receptor (GCCR), 2.5-fold less potency at the GLP-1 receptor, and 8.9-fold greater potency at human GIP receptor [1]

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The rapid drop in weeks 1 to 2 is largely water and glycogen, not fat

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Never adjust your dose without explicit guidance from your prescribing clinician or trial team

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