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Anti-TNF antibodies such as adalimumab block TNF- binding to its receptors, reduce inflammatory mediator release, and alleviate inflammation and tissue damage (67)

Additionally, the treatment upregulated synaptic proteins such as PSD 95 and Arc, which are crucial for synaptic plasticity and cognitive function [69] (Fig

There are risks for maternal, fetal, and neonatal toxicity

This cycling allows receptors to resensitize and natural hormonal systems to normalize

The increase in calcium helps inhibit TNF--stimulated activation of NF-B, a key driver of inflammation