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Notably, in most countries PAC is freely sold as an OTC drug, raising the risk of unintentional abuse and increased adverse effects (Sansgiry et al., 2017)

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doi: 10.3389/fgene.2018.00579 130 de CalignonAFoxLMPitstickRCarlsonGABacskaiBJSpires-JonesTLet al

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The animals were then deeply anesthetized with 3% isoflurane and 50 mg/kg of ketamine followed by a laminectomy at lumbar level L2-L3, corresponding to the sacrocaudal spinal cord