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Methylation issues are very common (up to 40% of patients) and many patients unknowingly supplement with cyanocobalamin which may increase serum levels but will not improve symptoms 5
I have used this before with great success
The Take-Away Its important to note that while many people report positive effects from MIC/B-12 injections, the evidence supporting these benefits is limited
NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )
Hydroxocobalamin injection should be given only intramuscularly
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