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PubMed record Solnier J, et al

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Because semaglutide has a 7-day half-life, some drug remains in your system even 4 days after a missed dose

Fatigue: Some users report feeling tired or experiencing headaches

In both cohorts, only 37 individuals originally assigned to the placebo completed it without receiving an active treatment (e.g., orforglipron rescue or other obesity medication), which complicates the interpretation of placebo comparisons after week 24