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It is important to note that PPA affects multiple systems in a complex manner and the evidence of increased PPA or other short-chain fatty-acids being involved in the pathophysiology of ASD, although compelling, is circumstantial at this stage
The trial did not measure body composition, so waist and weight trajectories cannot establish fat-versus-lean partition
For example, patients with specific GLP1R variants may require higher doses of semaglutide or respond better to dual-mechanism therapy like tirzepatide
The FDA has received 489 reports of anxiety, depression, or suicidal thoughts in patients taking semaglutide medications, including 96 cases specifically involving suicidal thoughts [8]
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