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Topical limitations: Limited penetration beyond superficial skin layers
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This is upstream of histamine release, meaning it prevents the problem rather than managing its consequences
doi: 10.1111/petr.13129 60 MontgomeryRAOrandiBJRacusenLJacksonAMGaronzik-WangJMShahTet al
The pyroptotic process is typically initiated by recognition of pathogens in the cytosol or endogenous danger signals via inflammasomes, which recruit and activate inflammatory caspases such as caspase-1, -4, -5, -11 (160, 161)
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