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When you start any medication with a long half-life, the first several doses are building toward a stable baseline

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With the caveat that youll gain a little bit back but not a huge amount. For its part, Calibrate says it has the interests of its patients at heart, and that its acknowledging the fact that many of them are not going to stay on weight-loss drugs for life, given supply-chain shortages, insurance coverage limits, medication costs, issues with side effects, or them not wanting to stay on a medication forever