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It is a 47-residue synthetic peptide constructed as a D-retro-inverso (DRI) analog: the primary sequence is reversed and each amino acid is substituted with its D-enantiomer, an arrangement that approximates the topological side-chain presentation of the parent L-peptide while conferring markedly greater resistance to proteolytic degradation in typical aqueous and biological buffer systems used at the bench
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Clinical measurements using cutometer analysis revealed a 70% increase in skin elasticity after 12 weeks of GHK-Cu application
10.1016/s0928-4257(01)00040-7 83 Stancic-RokotovD.SlobodnjakZ.AralicaJ.AralicaG.PerovicD.StaresinicM.et al (2001b)
These changes occurred through direct effects on adipocyte biology rather than appetite suppression, as research models maintained normal feeding behavior while exhibiting significant reductions in individual adipocyte size
