The primary reason is a lack of blood supply
Why It Works: Delivers copper as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes needed to cross-link and stabilize new collagen Upregulates COL1A1 and COL1A2 collagen gene transcription along with elastin, decorin, and glycosaminoglycan production while modulating matrix metalloproteinase activity for balanced remodeling Promotes angiogenesis and fibroblast proliferation
Slowing an infusion may help some rate-related symptomsbut does not diagnose them Chest symptoms, low blood pressure, breathing difficulty, severe pain, or neurologic symptoms require assessment rather than automatic continuation at a slower rate
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Frontiers in Cell and Developmental Biology, 13 , 1633166 Shang, Y., Song, N., He, R., & Wu, M
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