These receptors activate intracellular cascades mediated by gustducin, phospholipase C beta 2 (PLC2), inositol triphosphate (IP3), and Transient Receptor Potential Melastatin 5 (TRPM5), leading to the release of ATP as a neurotransmitter (2, 24, 47)
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The complexes were solubilized from membrane using detergent (1% (w/v) LMNG and 0.06% (w/v) CHS) for 1 h at 4 C
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CSD acts by mimicking the inhibitory effect of full-length CAV-1 on signaling 7