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Inducers of NRF2, such as SF, interact with specific cysteine residues of KEAP1 leading to dissociation or degradation of the Cul3KEAP1 complex and stabilization of NRF2, which translocates to the nucleus activating ARE-dependent genes (Zhang et al., 2004

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As a result, the existing recommendations on how to dose this compound largely stem from animal studies and anecdotal reports

The mix was incubated for 2 min and then 1 l of Thermoscript reverse transcriptase (200 U) (Invitrogen) was added and incubated for 50 min at 42 C

Improper handling of the powder might cause it to lose its quality shortly

doi: 10.24095/hpcdp.36.9.03 62 RitchieI