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Therefore, dual GLP-1/glucagon co-agonists, such as survodutide [82], cotadutide [83] and pemvidutide [84] yield greater improvements in hepatic steatosis and fibrosis biomarkers than GLP-1 monotherapy, reflecting additive modulation of mitochondrial and inflammatory pathways
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Tirzepatide (Zepbound and Mounjaro): weekly vials you load into a syringe yourself or preloaded injection pens Semaglutide (Wegovy and Ozempic): weekly, preloaded injection pen in various doses Liraglutide (Saxenda and Victoza): daily injectable pens Other GLP-1s and weight-loss meds: Trulicity , a less common GLP-1 (dulaglutide), comes in the form of a pen for once-weekly injections Bydureon BCise (once-weekly preloaded injection) Rybelsus (oral method) Contrave and Xenical (weight-loss drugs that are not GLP-1s and typically come at a much cheaper price tag) Other medications: antibiotics, antidepressants, asthma medication, and much, much more Note: Ozempic, Mounjaro, Victoza, Trulicity, Bydureon, and Rybelsus are FDA approved for type 2 diabetes only and must be prescribed off-label for use as a weight-loss treatment

Tirzepatide , a dual GIP/GLP-1 receptor agonist, has been approved in the UK for type 2 diabetes (as Mounjaro) but at the time of writing is not licensed by the MHRA specifically for weight management
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