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TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig
Lara Devgan NAD+ Glutathione Serum The Dr
When the blood selenium increment was within a specific range, the risk of CVD death decreased in a dose-dependent manner, but it seemed to start to increase when the increment exceeded 35 g/L [116]
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