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Animal models extend further, with 90-day rat toxicology data published in 2021 showing no organ damage at doses up to 50mg/kg daily, but extrapolating rodent data to human long-term safety requires caution we don't take lightly

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Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet