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The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For

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The synthesis of GCL, along with other targets involved in the antioxidant response, is under the control of the transcription factor, Nrf2 (Baird and Dinkova-Kostova 2011)

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