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IFN, a potent anti-fibrogenic cytokine produced by NK cells, was conjugated to a cyclic peptide recognizing the platelet-derived growth factor beta receptor (PDGFR) that was found strongly upregulated on activated HSCs

In another study, a history of laparoscopy had an association with colonic ischemia with an odds ratio of 2.9 [11]

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Mechanical forces applied to connective tissues alter the gene expression pattern and activity of fibroblasts, as mechanical signals are converted into intracellular signalling events, a process called mechanotransduction

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