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Ryan et al., 2020) used C57BL/6 mice to construct a high-fat diet (HFD)-induced diabetes model followed by metformin treatment

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In a Phase 2a trial specifically evaluating liver outcomes, retatrutide achieved an average 82% reduction in liver fat content

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When indicated, medications like tirzepatide and Ozempic can be integrated with physical therapy, nutritional counseling, and lifestyle modifications to maximize results and enhance overall well-being