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Fasting insulin levels, HOMA-IR (a measure of insulin resistance), high-sensitivity C-reactive protein (an inflammation marker), liver enzymes (indicators of fatty liver disease), and advanced lipid panels all provide evidence of metabolic dysfunction that weight alone cannot capture

Further, our analyses revealed that the multi-omics signature associated with higher circulating TMAO concentrations and, therefore, elevated cardiovascular risk, shifted from obesity with increased insulin resistance toward overt T2D and IHD with only three variables (age, eGFR, and serum butyryl-carnitine) consistently being strong contributors across models built with the BMIS, T2D and IHD disease groups

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Semaglutide is marketed under different brand names, such as Ozempic for type 2 diabetes management and Wegovy for weight loss