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Interestingly, low oxygen levels are also required to maintain embryonic stem cells (ESCs) and muscle stem cells (MuSCs) in a self-renewing, undifferentiated state (Mazumdar et al., 2010
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This process may further activate the NLRP3 inflammasome, resulting in excessive release of inflammatory cytokines such as IL-1 and amplifying systemic inflammation (97)
2021;320(4):G61726
Updated January 31, 2025
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