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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+
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Associated with elevated NAD+ levels and SIRT1 activation in preclinical studies [2] [3]
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The DIO mice were randomized into three treatment groups balanced by baseline body weight and body composition (fat and lean mass) measures
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