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If medically necessary for a patient, healthcare providers can prescribe compounded medications with similar mechanisms of action to gain greater control of the patient-specific disease process being treated

Time to first occurrence of confirmed MACE-4 for SURPASS-4 only (tirzepatide versus insulin glargine in a high-cardiovascular-risk population) demonstrated an HR of 0.74 (95% CI, 0.511.08) ( P = 0.123) (Extended Data Fig

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Combination Approaches Future treatments might combine incretin agonists with other weight loss mechanisms like metabolism boosters, appetite suppressants working through non-incretin pathways, or fat absorption inhibitors