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425,426 In the heart tissue of conditional frataxin knockout mice, increased mRNA levels of MFRN2, SEC15L1, and TFR1 and decreased mRNA levels of FPN1 indicate an activated response to cytoplasmic iron deficiency and increased mitochondrial iron input

Concerns include reports of adverse events, some requiring hospitalization, that may be related to dosing errors or doses beyond what is in the FDA-approved drug label, which means using more product in a single dose, taking doses more frequently or increasing the amount more quickly (titration schedule)

Additionally, Python was employed to develop computational tools for PROTAC ternary model construction

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